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BPSL1424 BPSL1424 BPSL1426 BPSL1426 BPSL0062 BPSL0062 phbA phbA BPSL1540 BPSL1540 BPSL0371 BPSL0371 BPSL0650 BPSL0650 BPSS0486 BPSS0486 paaJ paaJ pcaF pcaF BPSL0377 BPSL0377
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
BPSL1424Putative fatty acid degradation protein (possibly trifunctional); Similar to Ralstonia solanacearum probable trifunctional: enoyl-CoA hydratase and delta3-cis-delta2-trans-enoyl-CoA isomerase and 3-hydroxyacyl-CoA dehydrogenase oxidoreductase protein rsc1759 or rs02946 SWALL:Q8XYJ9 (EMBL:AL646066) (706 aa) fasta scores: E(): 2.4e-192, 74.6% id in 693 aa, and to Escherichia coli fatty oxidation complex alpha subunit [includes: enoyl-CoA hydratase; delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase; 3-hydroxyacyl-CoA dehydrogenase; 3-hydroxybutyryl-CoA epimerase] FadB or OldB or b3846 SWALL [...] (694 aa)    
Predicted Functional Partners:
BPSL1426
Putative thiolase; Similar to Ralstonia solanacearum probable acetyl-CoA acetyltransferase protein rsc1761 or rs02948 SWALL:Q8XYJ7 (EMBL:AL646066) (392 aa) fasta scores: E(): 1.6e-124, 85.2% id in 392 aa, and to Pseudomonas aeruginosa probable acyl-CoA thiolase pa3454 SWALL:Q9HYF2 (EMBL:AE004766) (394 aa) fasta scores: E(): 4.5e-74, 53.69% id in 393 aa; Belongs to the thiolase-like superfamily. Thiolase family.
 0.998
BPSL0062
Similar to Pseudomonas putida beta-ketoadipyl CoA thiolase PcaF SWALL:PCAF_PSEPU (SWALL:Q51956) (400 aa) fasta scores: E(): 8e-34, 41.8% id in 421 aa, and to Caulobacter crescentus fatty oxidation complex, beta subunit, putative CC0077 SWALL:Q9ABZ3 (EMBL:AE005682) (401 aa) fasta scores: E(): 5.5e-95, 71% id in 400 aa; Belongs to the thiolase-like superfamily. Thiolase family.
 0.996
phbA
Similar to Alcaligenes eutrophus acetyl-CoA acetyltransferase PhbA SWALL:THIL_ALCEU (SWALL:P14611) (393 aa) fasta scores: E(): 4.9e-117, 85.96% id in 392 aa, and to Burkholderia sp. DSMZ 9242 PhaA SWALL:Q9RB81 (EMBL:AF153086) (393 aa) fasta scores: E(): 9.4e-127, 92.36% id in 393 aa. Note: Also similar to BPSL1540 (418 aa) fasta scores: E(): 6e-62, 52.806% identity in 392 aa overlap and to BPSL0371 (398 aa) fasta scores: E(): 7.2e-59, 50.643% identity in 389 aa overlap; Belongs to the thiolase-like superfamily. Thiolase family.
 0.996
BPSL1540
Similar to Alcaligenes eutrophus beta-ketothiolase BktB SWALL:O68275 (EMBL:AF026544) (394 aa) fasta scores: E(): 3.2e-114, 79.44% id in 394 aa, and to Alcaligenes eutrophus acetyl-CoA acetyltransferase PhbA SWALL:THIL_ALCEU (SWALL:P14611) (393 aa) fasta scores: E(): 6.3e-67, 52.04% id in 392 aa. Note: Also similar to BPSL1535 (394 aa) fasta scores: E(): 1.8e-61, 52.806% identity in 392 aa overlap; Belongs to the thiolase-like superfamily. Thiolase family.
 0.996
BPSL0371
Similar to Alcaligenes eutrophus acetyl-CoA acetyltransferase PhbA SWALL:THIL_ALCEU (SWALL:P14611) (393 aa) fasta scores: E(): 1.5e-65, 48.84% id in 389 aa, and to Ralstonia solanacearum probable acetyl-CoA acetyltransferase rsc0276 or rs03243 SWALL:Q8Y2Q9 (EMBL:AL646058) (393 aa) fasta scores: E(): 6.7e-109, 74.42% id in 391 aa. Similar to BPSL1535, 50.643% identity (51.036% ungapped) in 389 aa overlap; Belongs to the thiolase-like superfamily. Thiolase family.
 0.995
BPSL0650
Similar to Rattus norvegicus 3-ketoacyl-CoA thiolase A, peroxisomal precursor SWALL:THIJ_RAT (SWALL:P21775) (434 aa) fasta scores: E(): 2.6e-55, 46.95% id in 394 aa, and to Ralstonia solanacearum putative acetyl-CoA acyltransferase protein rsc0475 or rs04420 SWALL:Q8Y261 (EMBL:AL646059) (399 aa) fasta scores: E(): 2.5e-124, 83.7% id in 399 aa. R. norvegicus protein is extended at the N-terminus in comparison to CDS; Belongs to the thiolase-like superfamily. Thiolase family.
 
 0.995
BPSS0486
N-terminal region similar to Streptomyces atroolivaceus non-ribosomal peptide synthetase SWALL:AAN85512 (EMBL:AF484556) (1745 aa) fasta scores: E(): 2.8e-67, 36.51% id in 838 aa, and C-terminal region similar to Pseudomonas aeruginosa probable acyl-CoA dehydrogenase pa1631 SWALL:Q9I391 (EMBL:AE004590) (384 aa) fasta scores: E(): 2e-23, 32.13% id in 361 aa.
  
 0.978
paaJ
Similar to Escherichia coli probable beta-ketoadipyl CoA thiolase PaaJ or b1397 SWALL:PAAJ_ECOLI (SWALL:P77525) (401 aa) fasta scores: E(): 2.1e-101, 68.32% id in 401 aa, and to Pseudomonas putida beta-ketoadipyl CoA thiolase PcaF SWALL:PCAF_PSEPU (SWALL:Q51956) (400 aa) fasta scores: E(): 2.8e-106, 73.56% id in 401 aa; Belongs to the thiolase-like superfamily. Thiolase family.
 0.963
pcaF
Beta-ketoadipyl CoA thiolase; Previously sequenced as Burkholderia pseudomallei beta-ketoadipyl CoA thiolase PcaF SWALL:Q9F4K2 (EMBL:AY007371) (400 aa) fasta scores: E(): 1.8e-145, 100% id in 400 aa. Similar to Pseudomonas putida beta-ketoadipyl CoA thiolase PcaF SWALL:PCAF_PSEPU (SWALL:Q51956) (400 aa) fasta scores: E(): 7.4e-106, 73.56% id in 401 aa; Belongs to the thiolase-like superfamily. Thiolase family.
 0.963
BPSL0377
Hypothetical protein; Similar to the N-terminal regions of Ralstonia solanacearum probable acetyl-CoA acetyltransferase rsc0276 or rs03243 SWALL:Q8Y2Q9 (EMBL:AL646058) (393 aa) fasta scores: E(): 4.5e-14, 39.81% id in 211 aa, and Pseudomonas aeruginosa probable acyl-CoA thiolase pa2553 SWALL:Q9I0T1 (EMBL:AE004683) (396 aa) fasta scores: E(): 2e-12, 37.93% id in 203 aa.
  
 0.953
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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